Key molecule that blocks Alzheimer’s progress found
A team of British scientists have discovered the molecule that can lock the progress of Alzheimer’s disease at an important stage in its development.
A molecular chaperone has been identified by scientists that inhibits an important stage in the development of Alzheimer’s and it also breaks a chain of toxic reactions that kills brain cells. The research also provides a basis for finding candidate molecules that can be used to treat Alzheimer’s.
Scientists from the Cambridge University have shown that a molecular chaperone, which is a type of molecule that occurs naturally in humans is working as an inhibitor that parts way through the molecular process and it is thought to cause Alzheimer’s disease.
This molecule, called Brichos, sticks to threads made of malfunctioning proteins which are called amyloid fibrils, that are a hallmark of the disease. While doing so, this protein comes into contact with other protein and prevents the formation of toxic clusters that serve as a catalyst in the process.
When fibrils that are made up of malfunctioning proteins that assist in the formation of toxic clusters is one of the critical stages in the development of the disease. When it’s known which molecule prevents the disease, researchers have moved closer to a cure for the disease. They now know which molecule can be used to treat it. This discovery has now been made possible by a strategy that can be applied to discover other similar molecules that exhibit the same capabilities.
This has also extended the range of options for drug development in future. Lead author of the study Dr Samuel Cohen said, “Our study shows, for the first time, one of these critical processes being specifically inhibited, and reveals that by doing so we can prevent the toxic effects of protein aggregation that are associated with this terrible condition.”